Nasopharyngeal cancer is a rare type of cancer that affects the part of the throat connecting the back of the nose to the back of the mouth (the pharynx).
In the UK, only about 240 people are diagnosed with nasopharyngeal cancer each year.
It's often difficult to recognise nasopharyngeal cancer because the symptoms are similar to other, less serious conditions. Also, many people with nasopharyngeal cancer don't have any symptoms until the cancer reaches an advanced stage.
Symptoms of nasopharyngeal cancer can include:
See your GP if you develop any worrying symptoms, particularly if they don't improve after a few weeks. While they're very unlikely to be caused by nasopharyngeal cancer, it's best to get them checked out.
The exact cause of nasopharyngeal cancer is unknown, but a number of factors can increase your risk of developing the condition. These include:
Being exposed to the human papilloma virus (HPV) may also increase your risk of developing certain types of nasopharyngeal cancer.
About three times as many men as women are affected by nasopharyngeal cancer, and the average age at diagnosis is about 50.
If you see your GP with symptoms that could indicate nasopharyngeal cancer, they'll usually ask about your symptoms and carry out some examinations. This may involve examining your throat using a small mirror and a light.
If your GP thinks further tests are necessary, they'll refer you to hospital. At hospital, a number of different tests may be carried out to check for nasopharyngeal cancer and rule out other conditions.
Some of the tests you may have include:
Once these tests are complete, your doctors will be able to confirm whether you have nasopharyngeal cancer. They'll also be able to "stage" the cancer, which means giving it a score to describe how large it is and how far it has spread.
The Cancer Research UK website has more information about the stages of nasopharyngeal cancer.
If you're diagnosed with nasopharyngeal cancer, you'll be cared for by a team of different specialists who work together called a multidisciplinary team (MDT). Members of your MDT will discuss with you what they think the best treatment option is in your case.
The two main treatments for nasopharyngeal cancer are:
In most cases, a combination of radiotherapy and chemotherapy will be used.
Surgery isn't usually used to treat nasopharyngeal cancer as it's difficult for surgeons to access the affected area.
Radiotherapy is the most commonly used treatment for nasopharyngeal cancer. It can be used on its own to treat very early-stage cancers, or in combination with chemotherapy for more advanced cancers.
In most cases, external radiotherapy is used. This involves using a machine to focus high-energy radiation beams on to the area that requires treatment.
In nasopharyngeal cancer, an advanced form of external radiotherapy called intensity-modulated radiation therapy (IMRT) is used.
It involves aiming radiation beams of different strengths at a tumour from several different angles. This helps maximise the dose delivered to the tumour, while minimising the effect on the surrounding healthy tissue.
Stereotactic radiotherapy is another way of giving radiotherapy externally and may be used to target a specific area where the cancer has returned.
External radiotherapy is often given in short sessions, once a day from Monday to Friday, with a break at weekends. This is usually carried out for up to seven weeks. You won't need to stay in hospital overnight between these appointments.
In some cases, internal radiotherapy may be required where nasopharyngeal cancer has returned after initial treatment. A radioactive source is placed into or near the cancerous area and left in place for anywhere from a few minutes to a few days.
Depending on the type of treatment you have, you may need to stay in hospital for a short period of time.
Radiotherapy itself is painless, but it can have some significant side effects, such as:
These side effects are usually temporary, but some can be permanent. Let your care team know if you experience these problems as treatment is often available to help.
Chemotherapy may be used before or alongside radiotherapy for more advanced nasopharyngeal cancers.
It's usually given through a drip into a vein (intravenous chemotherapy), with sessions every three to four weeks spread over several months. You won't usually need to stay in hospital overnight during treatment.
Like radiotherapy, chemotherapy can cause a number of significant side effects, such as:
These side effects are usually temporary, but there's also a risk of longer-term problems, such as infertility. You should discuss any concerns you have about the potential side effects of treatment with your care team before treatment begins.
After your course of treatment ends, you'll need to have regular follow-up appointments and scans to monitor your recovery and check for any signs of the cancer returning.
To start with, these appointments will be every few weeks or months, but they'll become gradually less frequent over time.
The outlook for nasopharyngeal cancer depends on your age, general health and how advanced the condition is when you're diagnosed.
Radiotherapy alone can cure many very early-stage nasopharyngeal cancers, but many cases are diagnosed at a more advanced stage as the condition doesn't always cause obvious symptoms until later on.
More advanced cancers are treated with a combination of chemotherapy and radiotherapy. They're often curable if the cancer hasn't spread beyond the head and neck region.
Overall, about 50 out of every 100 people (50%) diagnosed with nasopharyngeal cancer will live for five years or more after diagnosis.
Survival rates are better for younger people, but worse for older people. Around 70 out of 100 (70%) people under 45 years of age, and 35 out of 100 (35%) people aged 65 to 74, will live for five years or more after being diagnosed with nasopharyngeal cancer.
You can read more about the statistics and outlook for nasopharyngeal cancer on the Cancer Research UK website.